Endocrine Abstracts

Objective: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, with a female to male ratio of 3:1. Currently most patients with PHPT are asymptomatic. However, data about the gender impact on the clinical presentation of PHPT are lacking.Methods: We evaluated the difference in symptoms and biochemical parameters between men and women with PHPT in a single center series of 417 patients.Results: Male PHP...

Introduction: Current guidelines for the management of asymptomatic primary hyperparathyroidism (A-pHPT) recommend that 25-hydroxyvitamin D levels should be assessed in all patients and vitamin D deficiency (VDD) should be cautiously corrected. It is unknown whether VDD affects the probability to meet surgical criteria currently proposed for A-pHPT. Aim of study was to evaluate whether VDD recognition affects the probability to meet surgical criteria in A-pHPT patients.<p ...

A regulatory role of the skeleton on glucose metabolism has been supposed both in animals and in humans. Osteocalcin (OC) seems to be involved in this regulation and has been reported to be inversely associated with insulin resistance and measures of adiposity in different populations of adult subjects. Primary hyperparathyroidism (PHPT) is a condition mostly affecting elderly subjects and characterized by both marked increased bone turnover and increased insulin resistance. T...

Introduction: In primary hyperparathyroidism (PHPT) bone involvement is frequent. In women with PHPT it has been previously reported that menopausal status together with PTH, calcium levels and renal function are independent predictors of bone density. In male subjects, the impact of PHPT on bone status is less defined.Aim of the study: To investigate this study was possible predictors of bone mineral density (BMD) in a series of male subjects affected b...

Aim: Osteoporosis is common in postmenopausal women and in primary hyperparathyroidism (PHPT). PHPT is more prevalent in postmenopausal women. Aim of the present study was to investigate possible predictors of bone mineral density (BMD) in women with PHPT.Methods: 166 consecutive women with PHPT [age: 59.5±13.5 years; Asymptomatic/Symptomatic: 84/82; premenopausal/postmenopausal: 31/135; BMI: 25.6±4.8 kg/m2; PTH: 234.2±287.3 pg/...

Objective: Primary hyperparathyroidism (PHPT) and thyroid diseases are common in the general population. It is difficult to establish whether they occur in the same patient because of a direct relationship or just due to the widespread prevalence of both conditions. The reported prevalence of the concomitant occurrence of these two clinical conditions is widely scattered (ranging 17–84%), especially due to the heterogeneous criteria for patient selection. We aimed to eval...